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Together, these characteristics make semaglutide a promising candidate for preclinical investigation and clinical translational studies in people with AUD

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Additionally, discontinuing the medication without maintaining significant lifestyle changes can lead to weight regain, as the body may respond by increasing hunger hormones like ghrelin

Preclinical studies with SAR425899 clearly demonstrated dual receptor agonism in vitro and in preclinical in vivo studies, with a higher potency for the GLP1R than for the glucagon receptor in order to counterbalance the GCGR mediated increase of blood glucose levels through GLP-1 agonism 11,12,13